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. 1980 Oct;77(10):6047-51.
doi: 10.1073/pnas.77.10.6047.

Regulation of Tn5 transposition in Salmonella typhimurium

D Biek, J R Roth

Regulation of Tn5 transposition in Salmonella typhimurium

D Biek et al. Proc Natl Acad Sci U S A. 1980 Oct.

Abstract

The drug-resistance element Tn5 transposes with high frequency immediately after entry into a cell. Establishment of Tn5 within a cell results in a decrease in this transposition frequency. This phenomenon resembles "zygotic induction" of repressible operons and prophages. Evidence is presented that Tn5 transposition is under negative control by a factor encoded within the element itself. Established Tn5 elements (that contain point mutations inactivating the resistance gene) are able to inhibit transposition of an incoming Tn5 element by a factor of 12- to 70-fold. Several deletion derivatives of Tn5 lack the ability to inhibit transposition.

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References

    1. J Bacteriol. 1968 Jul;96(1):215-20 - PubMed
    1. Proc Natl Acad Sci U S A. 1971 Dec;68(12):3158-62 - PubMed
    1. Mol Gen Genet. 1972;119(1):75-88 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Sep;72(9):3628-32 - PubMed
    1. J Bacteriol. 1977 Jan;129(1):407-14 - PubMed

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