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. 1980 Oct;127(3):187-93.
doi: 10.1007/BF00427192.

The effect of nisin on murein synthesis

P Reisinger, H Seidel, H Tschesche, W P Hammes

The effect of nisin on murein synthesis

P Reisinger et al. Arch Microbiol. 1980 Oct.

Abstract

Nisin inhibits murein synthesis with concomitant accumulation of undecaprenyl-pyrophospho-MurHAc(pentapeptide) (lipid intermediate I). This inhibition is caused by the formation of a complex between the antibiotic and lipid intermediate I. Undecaprenyl-pyrophospho-MurNAc(pentapeptide)-GlcNAc (lipid intermediate II) also forms a complex with nisin. However, when murein synthesis is inhibited by nisin, this latter complex is not formed since lipid intermediate II is not longer synthesized.

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References

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