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. 1980 Jul 15;190(1):119-23.
doi: 10.1042/bj1900119.

Evidence that catecholamines stimulate renal gluconeogenesis through an alpha 1-type of adrenoceptor

P Kessar, E D Saggerson

Evidence that catecholamines stimulate renal gluconeogenesis through an alpha 1-type of adrenoceptor

P Kessar et al. Biochem J. .

Abstract

1. Noradrenaline stimulates gluconeogenesis through an alpha-adrenoceptor in renal cortical tubule fragments from fed rats incubated with 5 mM-lactate. 2. The selective alpha 1-adrenoreceptor agonist methoxamine stimulated gluconeogenesis, but the selective alpha 2-adrenoceptor agonist clonidine was ineffective. 3. The selective alpha 1-adrenoceptor antagonist thymoxamine blocked the stimulatory effects on gluconeogenesis of noradrenaline and of oxymetazoline (a synthetic alpha-agonist). The selective alpha 2-adrenoceptor antagonist yohimbine was ineffective in this respect. 4. It is concluded that noradrenaline and oxymetazoline stimulate gluconeogenesis in rat kidney via an alpha 1-rather than an alpha 2-type of adrenoceptor.

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