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. 1981 Jan 22;289(5795):253-8.
doi: 10.1038/289253a0.

Nucleotide sequences at host-proviral junctions for mouse mammary tumour virus

J E Majors, H E Varmus

Nucleotide sequences at host-proviral junctions for mouse mammary tumour virus

J E Majors et al. Nature. .

Abstract

Proviruses cloned from rat cells infected with mouse mammary tumour virus, a B-type retrovirus regulated by glucocorticoid hormones, show the structural features of transposable elements: short inverted repeats conclude long direct repeats at the ends of viral DNA, and short sequences of cellular DNA are duplicated during integration and flank each provirus. The integrative mechanism joins a precise site in viral DNA to non-homologous sites in host DNA.

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