Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Nov;77(11):6468-72.
doi: 10.1073/pnas.77.11.6468.

The inverted repeat as a recognizable structural feature in supercoiled DNA molecules

D M Lilley

The inverted repeat as a recognizable structural feature in supercoiled DNA molecules

D M Lilley. Proc Natl Acad Sci U S A. 1980 Nov.

Abstract

The single-strand-specific endonuclease S1 from Aspergillus oryzae introduces highly selective cleavages into supercoiled covalently closed circular DNA molecules, but not into their previously linearized counterparts. The cleavage sites are inverted repeats of unit length between 9 and 13 base pairs, separated by a nonrepetitious 2-6 base pairs. Such regions may adopt hairpin or similar structures stabilized by the negative superhelix density and may constitute recognition sites for cellular proteins.

PubMed Disclaimer

References

    1. Biochim Biophys Acta. 1966 Jan 18;114(1):158-68 - PubMed
    1. J Mol Biol. 1971 Jan 28;55(2):293-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1971 Apr;68(4):815-9 - PubMed
    1. J Mol Biol. 1972 May 14;66(2):307-9 - PubMed
    1. J Mol Biol. 1972 Nov 14;71(2):127-47 - PubMed

LinkOut - more resources