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. 1980 Aug 15;190(2):421-9.
doi: 10.1042/bj1900421.

Metabolism of adenine nucleotides by ectoenzymes of vascular endothelial and smooth-muscle cells in culture

J D Pearson, J S Carleton, J L Gordon

Metabolism of adenine nucleotides by ectoenzymes of vascular endothelial and smooth-muscle cells in culture

J D Pearson et al. Biochem J. .

Abstract

1. Pig aortic endothelial and smooth-muscle cells in culture rapidly catabolize exogenous ATP, ADP or AMP. 2. In both cell types catabolism is due to Mg2+-stimulated ectoenzymes. 3. Inhibition and substrate-specificity studies suggest that both cell types possess three distinct ectonucleotidases, namely nucleoside triphosphatase (EC 3.6.1.15), nucleoside diphosphatase (EC 3.6.1.6) and 5'-nucleotidase (EC 3.1.3.5), as well as nucleoside diphosphate kinase (EC 2.7.4.6). 4. These ectonucleotidase systems could be of importance in the regulation of neurotransmission, blood platelet function and vasodilation.

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