Controlled release of biologically active compounds from bioerodible polymers

Abstract

This article reviews the controlled release of biologically active agents by the erosion or chemical degradation of a polymer matrix into which the agent is incorporated. Chemically bound active agents and work on steroid release from cholesterol implants are not covered. The mechanisms of polymer erosion discussed are: cross-linked scission; hydrolysis, ionization or protonation of pendant groups; backbone cleavage. Drug release studies are dealt with under each of these headings.