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. 1980 Nov 21;68(2):181-5.
doi: 10.1016/0014-2999(80)90319-2.

Opiate and peptide interaction: effect of enkephalins on morphine analgesia

N M Lee, L Leybin, J K Chang, H H Loh

Opiate and peptide interaction: effect of enkephalins on morphine analgesia

N M Lee et al. Eur J Pharmacol. .

Abstract

Interactions between the weakly analgesic enkephalins and morphine on morphine-induced analgesia were studied. Met-enkephalin exhibited morphine analgesia whereas Leu-enkephalin potentiated it. Both Met- and Leu-enkephalin, when tested alone, were not analgesic. The strongly analgesic FK33824 (Sandoz) compound, like Leu-enkephalin, also potentiated morphine analgesia. Tolerance developed to morphine analgesia but not to Met-enkephalin inhibition of morphine analgesia.

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