Effect of ergoline derivative VUFB-6638 on the adenohypophysial prolactin concentration in rats
- PMID: 6259
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Effect of ergoline derivative VUFB-6638 on the adenohypophysial prolactin concentration in rats
Endocrinol Exp.
1975 Jan.
Abstract
The compound VUFB-6638 (N-/D-6-methyl-8-isoergolin-I-yl/N'-N'-diethylurea hydrogen maleinate) was administered for four consecutive days to lactating rats in daily oral doses of 0.1, 1.0 and 2.0 mg/kg. The adenohypophysial prolactin concentration decreased by 34% to 68%, respectively. Moreover, this compound reduced or even completely suppressed the lactation. In view of the assumed relations between prolactin and breast carcinoma, a potential use of the drug is noted.
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Changes in the concentration of adenohypophyseal prolactin and morphological manifestations in the adenohypophysis of lactating rats after administration of D-6-methyl-8-[beta-isopropylaminoethyl] ergoline-I.Experientia. 1976 Oct 15;32(10):1308-9. doi: 10.1007/BF01953109. Experientia. 1976. PMID: 987925