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. 1978 Jan;67(1):83-7.
doi: 10.1111/j.1651-2227.1978.tb16281.x.

Factor VIII activity and antigen in sick newborns with pathological proteolysis in blood

P Henriksson, L Holmberg

Factor VIII activity and antigen in sick newborns with pathological proteolysis in blood

P Henriksson et al. Acta Paediatr Scand. 1978 Jan.

Abstract

Factor VIII clotting activity (VII:C) and factor VIII related antigen (VIII:R:AG) were determined in 12 sick newborn infants with pathological proteolysis in their circulation. A marked discrepancy was noted between VIII:R:AG and VIII:C, the ratio in sick infants being, on average, 2:1, while no discrepancy was seen in healthy newborns. The finding in the sick infants resembled a low grade plasminogen activation, which was studied experimentally. It is concluded that demonstration of a marked discrepancy between VIII:R:AG and VIII:C is a useful indication of pathologic proteolysis in sick newborns.

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