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. 1981 Jan;37(1):156-60.
doi: 10.1128/JVI.37.1.156-160.1981.

Structural polypeptides of simian rotavirus SA11 and the effect of trypsin

R T Espejo, S López, C Arias

Structural polypeptides of simian rotavirus SA11 and the effect of trypsin

R T Espejo et al. J Virol. 1981 Jan.

Abstract

Analysis of purified simian rotavirus has shown that it contains fewer structural polypeptide classes than previously reported. Two polypeptides (molecular weights, 62,000 and 28,000) commonly found in purified rotaviruses were, in fact, produced by cleavage of a larger structural polypeptide (molecular weight, about 88,000) by trypsin, which is usually employed to increase the yield of rotaviruses in tissue culture. Trypsin-uncleaved, double-shelled rotaviruses are probably composed of only five polypeptide classes; three in the inner layer, and two in the outer layer.

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