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. 1980 Dec;77(12):7357-61.
doi: 10.1073/pnas.77.12.7357.

No apparent nucleotide sequence specificity in cellular DNA juxtaposed to retrovirus proviruses

K Shimotohno, H M Temin

No apparent nucleotide sequence specificity in cellular DNA juxtaposed to retrovirus proviruses

K Shimotohno et al. Proc Natl Acad Sci U S A. 1980 Dec.

Abstract

The sequences of the virus-cell junctions of seven DNA clones of spleen necrosis virus provirus were analyzed to determine the nucleotide sequence specificity of the cellular integration sites. As previously reported for one provirus, all clones contain a 5-base-pair direct repeat of cellular DNA at the cell-virus junctions and a 3-base-pair inverted repeat at both ends of the provirus DNA. The sequences of the 5-base-pair direct repeats are different in each clone and have no apparent homology to viral DNA. No apparent common features and no sequences significantly homologous to the ends of the provirus DNA were found in the cellular DNAs surrounding the viral integration sites.

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References

    1. Cell. 1976 Oct;9(2):269-87 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Jan;74(1):281-5 - PubMed
    1. Science. 1977 Apr 8;196(4286):180-2 - PubMed
    1. Science. 1977 Sep 16;197(4309):1147-60 - PubMed
    1. Cell. 1978 Feb;13(2):387-98 - PubMed

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