Clinical Trial
Chemotherapy versus chemoimmunotherapy of head and neck cancer: report of a randomized study
- PMID: 62613
Item in Clipboard
Clinical Trial
Chemotherapy versus chemoimmunotherapy of head and neck cancer: report of a randomized study
Cancer Treat Rep.
1976 May.
Abstract
Thirty-four patients with recurrent squamous cell carcinoma of the head and neck were randomized to receive the five-drug chemotherapy regimen BACON (bleomycin, adriamycin, CCNU, vincristine [Oncovin], and mechlorethamine [nitrogen mustard]; 14 patients) or the same regimen plus bacillus Calmette-Gu erin (BCG) by scarification (20 patients). The majority of both patient groups had received prior surgery and radiation. The patients treated with BACON plus BCG experienced a significantly longer survival (P = 0.014) than those treated with BACON alone. There were five drug-related deaths, and eight other patients required hospitalization for treatment of drug-related morbidity.
Similar articles
-
Sequential combination chemotherapy for advanced squamous cell carcinoma of the head and neck.Laryngoscope. 1979 Dec;89(12):1921-9. doi: 10.1288/00005537-197912000-00004. Laryngoscope. 1979. PMID: 92740
-
Comparative trial of combination chemotherapy in extensive squamous carcinoma of the lung: a Southwest Oncology Group Study.Cancer Treat Rep. 1977 Dec;61(9):1623-9. Cancer Treat Rep. 1977. PMID: 74281 Clinical Trial.
-
Combination chemotherapy in squamous cell carcinoma of the lung.Chemioterapia. 1984 Apr;3(2):75-8. Chemioterapia. 1984. PMID: 6085285
-
Immunochemotherapy in 34 cases of oat cell carcinoma of the lung with 19 complete responses.Cancer Treat Rep. 1977 May-Jun;61(3):343-7. Cancer Treat Rep. 1977. PMID: 68827 Review.
-
Update in cancer chemotherapy, Part III: Lung cancer, Part 1.J Natl Med Assoc. 1985 Oct;77(10):815-27. J Natl Med Assoc. 1985. PMID: 2414458 Free PMC article. Review.
Cited by
-
Targeting the immune system: novel therapeutic approaches in squamous cell carcinoma of the head and neck.Cancer Immunol Immunother. 2004 Dec;53(12):1055-67. doi: 10.1007/s00262-004-0530-z. Cancer Immunol Immunother. 2004. PMID: 15095020 Free PMC article. Review.
-
Immunotherapy and chemoimmunotherapy of malignant disease with BCG and nonviable mycobacterial fractions.World J Surg. 1977 Sep;1(5):555-83. doi: 10.1007/BF01556181. World J Surg. 1977. PMID: 272083 No abstract available.
-
The concept of immunochemosurgery in gastric cancer.World J Surg. 1987 Aug;11(4):465-72. doi: 10.1007/BF01655811. World J Surg. 1987. PMID: 3630191 Clinical Trial. No abstract available.
-
Interventions for the treatment of oral and oropharyngeal cancers: targeted therapy and immunotherapy.Cochrane Database Syst Rev. 2015 Dec 1;2015(12):CD010341. doi: 10.1002/14651858.CD010341.pub2. Cochrane Database Syst Rev. 2015. PMID: 26625332 Free PMC article.
-
[Squamous cell carcinoma of the head and neck. Principles and current concepts of immunotherapy].HNO. 2005 Mar;53(3):285-97; quiz 298. doi: 10.1007/s00106-004-1167-0. HNO. 2005. PMID: 15759168 Review. German.