Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Jan;7(1):103-8.
doi: 10.1007/BF01544751.

Maternal inheritance of mitochondrial DNA polymorphisms in cultured human fibroblasts

J T Case, D C Wallace

Maternal inheritance of mitochondrial DNA polymorphisms in cultured human fibroblasts

J T Case et al. Somatic Cell Genet. 1981 Jan.

Abstract

We have isolated the total cellular DNA from the cultured diploid fibroblasts of a six-member, three-generation human family. Using a specific radioactive probe for mitochondrial (mt) sequences we have identified new polymorphic variants in this family for the Hhal restriction endonuclease cleavage pattern of the mtDNA. The inheritance of these cleavage patterns verifies the maternal inheritance of mtDNA through all three generations.

PubMed Disclaimer

Publication types

LinkOut - more resources