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Comparative Study
. 1981 Mar;78(3):1577-80.
doi: 10.1073/pnas.78.3.1577.

Tissue-specific exposure of chromatin structure at the 5' terminus of the rat preproinsulin II gene

C Wu, W Gilbert
Comparative Study

Tissue-specific exposure of chromatin structure at the 5' terminus of the rat preproinsulin II gene

C Wu et al. Proc Natl Acad Sci U S A. 1981 Mar.

Abstract

The 5' terminus of the rat preproinsulin II gene exhibits a tissue-dependent DNase I sensitivity. Only in the chromatin froma pancreatic beta-cell tumor, but not in liver, spleen, kidney, or brain chromatin, is a region at and before the 5' end of the gene exposed to cleavage. The region of exposure extends 250-300 base pairs upstream from the 5' terminus of the preproinsulin mRNA. Such a region may allow control sequences special access to regulatory proteins.

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References

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