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. 1980 Dec 15;192(3):947-50.
doi: 10.1042/bj1920947.

Ontogenic development of alpha-adrenergic receptors and responsiveness in white adipocytes

R Pecquery, Y Giudicelli

Ontogenic development of alpha-adrenergic receptors and responsiveness in white adipocytes

R Pecquery et al. Biochem J. .

Abstract

The influence of age on adipocyte alpha-adrenergic receptors was studied by using the binding of [3H]dihydroergocryptine to crude adipocyte membranes from hamsters of different ages (1-10 months). The number of alpha-receptor sites was found to increase with increasing age, but in contrast, their binding affinity remained unchanged. These changes in receptor concentrations, which were not related to cell-size differences, were also accompanied by parallel variations of the alpha-adrenergic responsiveness of the fat-cells.

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