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. 1981;100(1):51-8.
doi: 10.1007/BF00405901.

Scanning and transmission electron microscopy of cloned rat astrocytoma cells treated with dibutyryl cyclic AMP in vitro

A M Spence, P W Coates

Scanning and transmission electron microscopy of cloned rat astrocytoma cells treated with dibutyryl cyclic AMP in vitro

A M Spence et al. J Cancer Res Clin Oncol. 1981.

Abstract

Two cloned rat astrocytoma cell lines, 36 B-10 and 40 A-2, maintained in vitro were treated with 1 mM dibutyryl cyclic AMP. This treatment induced arborization of cellular processes and rounding-up of cell bodies in both cell lines and was associated with increased microvillous development in 40 A-2. There were not detectable concomitant changes in either (a) the quantity or organization of microtubules or 80-100 nm microfilaments, or (b) the intensity of glial fibrillary acidic protein indirect immunofluorescence staining.

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