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. 1981 Jan;78(1):474-8.
doi: 10.1073/pnas.78.1.474.

Linkage of the four gamma subclass heavy chain genes

W Roeder, R Maki, A Traunecker, S Tonegawa

Linkage of the four gamma subclass heavy chain genes

W Roeder et al. Proc Natl Acad Sci U S A. 1981 Jan.

Abstract

The genes for the heavy-chain constant regions of the four gamma subclass immunoglobulins were identified in a set of overlapping mouse DNA fragments representing about 100 kilobase pairs (kb) of the mouse genome that was cloned from bacteriophage lambda libraries of BALB/c mouse embryo DNA. R-loop mapping studies show that the genes are located 5'-C gamma 3-34 kb-C gamma 1-21 kb-C gamma 2b-15 kb-C gamma 2a-3' and lie in the same transcriptional orientation. Two DNA segments, one of 19 kb and another of 15 kb, that surround the C gamma 2b and C gamma 2a genes, respectively, show considerable homology and implicate a tandem duplication mechanism in the evolution of this gene cluster.

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