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. 1981 Apr;78(4):2204-7.
doi: 10.1073/pnas.78.4.2204.

A model for biological oscillations

T R Chay

A model for biological oscillations

T R Chay. Proc Natl Acad Sci U S A. 1981 Apr.

Abstract

A model and computation for oscillatory phenomena observed in some biological processes that utilize ion gradients across a membrane is presented. The model contains two main features: (i) active H+ transport pathways in the membrane and (ii) key enzymes having a pH-dependent activity profile and either translocating H+ from outside or producing H+ as a product. With this model a very long period of oscillations, as observed in mitochondrial and circadian rhythms, could be quantitatively demonstrated.

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