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. 1981 Apr;78(4):2606-10.
doi: 10.1073/pnas.78.4.2606.

Expression of the hepatitis B virus surface antigen gene in cell culture by using a simian virus 40 vector

A M Moriarty, B H Hoyer, J W Shih, J L Gerin, D H Hamer

Expression of the hepatitis B virus surface antigen gene in cell culture by using a simian virus 40 vector

A M Moriarty et al. Proc Natl Acad Sci U S A. 1981 Apr.

Abstract

We have constructed a simian virus 40 recombinant carrying a fragment of DNA from hepatitis B virus. Cultured monkey kidney cells infected with this recombinant produce hepatitis B surface antigen. The antigen is excreted into the culture medium as 22-nm particles with the same physical properties, antigenic composition, and constituent polypeptides as those found in the sera of patients with type B hepatitis.

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