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. 1981 May 22;71(4):489-93.
doi: 10.1016/0014-2999(81)90194-1.

Tetrahydroisoquinolines (TIQs) do not act on opiate receptors in the guinea-pig ileum

R A North, M A Collins, J D Milner, P J Karras, D J Koziol

Tetrahydroisoquinolines (TIQs) do not act on opiate receptors in the guinea-pig ileum

R A North et al. Eur J Pharmacol. .

Abstract

The myenteric plexus-longitudinal muscle preparation of the guinea-pig ileum was stimulated with supra-maximal electrical field stimulation at 0.1 Hz. The contractile response was inhibited by salsolinol (1-300 microM) and tetrahydropapaveroline (THP) (3-30 micro M) but not by (cis)-3-carboxysalsolinol. S(-)-Salsolinol was more potent than R(+)-salsolinol. The inhibition by salsolinol and THP was unchanged by naloxone (up to 10 micro M). However, naloxone completely prevented the inhibition induced by normorphine, with a pA2 of 8.66. The results indicate that salsolinol and THP do not interact with opiate receptors in this preparation.

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