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. 1981 Jan 15;27(1):107-11.
doi: 10.1002/ijc.2910270117.

Epstein-Barr virus-induced malignant lymphoma in a white-lipped marmoset

S K Sundar, P H Levine, D V Ablashi, S A Leiseca, G R Armstrong, J L Cicmanec, G A Parker, M Nonoyama

Epstein-Barr virus-induced malignant lymphoma in a white-lipped marmoset

S K Sundar et al. Int J Cancer. .

Abstract

One of six white-lipped marmosets inoculated with cell-free B95-8 virus developed diffuse malignant lymphoma. Epstein-Barr virus (EBV) DNA was detected in a pathologically enlarged mandibular lymph node by DNA-DNA hybridization. The affected animal at the time of killing had EBV antibody titers of 1:320 for viral capsid antigen (VCA) and 1:20 for early antigen (EA) while all non-diseased animals had less than or equal to 1:80 VCA antibody and no detectable EA antibody. This is the first report of lymphoma development in a white-lipped marmoset following EBV inoculation.

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