Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 1981 Aug;149(2):77-83.

Cyproheptadine in the control of Cushing's disease

T H Hsu, D S Gann, K W Tsan, R P Russell
  • PMID: 6265685
Case Reports

Cyproheptadine in the control of Cushing's disease

T H Hsu et al. Johns Hopkins Med J. 1981 Aug.

Abstract

A patient with Cushing's disease was treated with cyproheptadine with concomitant remission of the disease for 60 months. Despite clinical improvement and achievement of normal levels of cortisol excretions, her menstruation-related cyclic surge of cortisol secretion was supranormal. The mode of action of cyproheptadine was studied by the administration of metyrapone. Long-term administration of cyproheptadine appeared to normalize excessive adrenocorticotropic hormone (ACTH) production by reducing the frequency and the peak levels of episodic secretion of ACTH.

PubMed Disclaimer

Publication types

LinkOut - more resources