Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 May;78(5):3265-8.
doi: 10.1073/pnas.78.5.3265.

A highly potent 3200-dalton adrenal opioid peptide that contains both a [Met]- and [Leu]enkephalin sequence

D L Kilpatrick, T Taniguchi, B N Jones, A S Stern, J E Shively, J Hullihan, S Kimura, S Stein, S Udenfriend

A highly potent 3200-dalton adrenal opioid peptide that contains both a [Met]- and [Leu]enkephalin sequence

D L Kilpatrick et al. Proc Natl Acad Sci U S A. 1981 May.

Abstract

A 3200-dalton adrenal enkephalin-containing peptide, designated peptide E, that exhibits high opiate activity in the guinea pig ileum longitudinal muscle preparation was purified, and its structure was determined. It contains an amino-terminal [Met]enkephalin sequence and a [Leu]enkephalin sequence at the carboxyl terminus. Sequence analysis revealed that peptide E arises from a previously characterized 4900-dalton adrenal enkephalin-containing peptide. Peptide E was shown to be 30 times more potent than [Met]enkephalin in the guinea pig ileum assay, which suggests that the adrenal enkephalin-containing peptide may perform a unique biological function in vivo.

PubMed Disclaimer

References

    1. Br J Pharmacol. 1970 Jun;39(2):398-413 - PubMed
    1. Arch Biochem Biophys. 1973 Mar;155(1):202-12 - PubMed
    1. Biochem Biophys Res Commun. 1979 Jan 15;86(1):153-60 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Dec;76(12):6666-70 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Dec;76(12):6680-3 - PubMed

LinkOut - more resources