Opioid inhibition of dopamine release from nervous tissue of Mytilus edulis and Octopus bimaculatus
- PMID: 6266017
- DOI: 10.1126/science.6266017
Opioid inhibition of dopamine release from nervous tissue of Mytilus edulis and Octopus bimaculatus
Abstract
Morphine and D-Ala2-Met-enkephalin as well as other opioids suppress potassium-stimulated release of 3H-labeled dopamine from neurons tissue of two marine invertebrates, Mytilus edulis and Octopus bimaculatus. Naloxone reverses the inhibitory effects in both species. Potassium-stimulated release of 3H-labeled serotonin is not altered by opioids. It is postulated that opiate receptors and their endogenous effectors play a prominent role in regulation of transmitter release in invertebrates.
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