doi: 10.1016/0006-8993(81)90522-9.
Muscarinic-dopaminergic synergism on retinal cyclic AMP formation
- PMID: 6266579
- DOI: 10.1016/0006-8993(81)90522-9
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Muscarinic-dopaminergic synergism on retinal cyclic AMP formation
Brain Res.
.
Abstract
The cholinergic agonist, carbachol, produces a small increase in cyclic AMP concentration in the isolated rat retina, and markedly potentiates dopamine-stimulated cyclic AMP formation. This effect of carbachol is mediated through a muscarinic receptor, is calcium-independent, and is not due to inhibition of phosphodiesterase activity. Activation of muscarinic receptors may potentiate dopaminergic responses in the retina by enhancing coupling of the dopamine receptor to adenylate cyclase.
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