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. 1981 Jun 29;215(1-2):388-92.
doi: 10.1016/0006-8993(81)90522-9.

Muscarinic-dopaminergic synergism on retinal cyclic AMP formation

J H Brown, M Rietow

Muscarinic-dopaminergic synergism on retinal cyclic AMP formation

J H Brown et al. Brain Res. .

Abstract

The cholinergic agonist, carbachol, produces a small increase in cyclic AMP concentration in the isolated rat retina, and markedly potentiates dopamine-stimulated cyclic AMP formation. This effect of carbachol is mediated through a muscarinic receptor, is calcium-independent, and is not due to inhibition of phosphodiesterase activity. Activation of muscarinic receptors may potentiate dopaminergic responses in the retina by enhancing coupling of the dopamine receptor to adenylate cyclase.

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