doi: 10.1016/0378-1119(81)90032-9.
Extrachromosomal rDNA of Tetrahymena thermophila is not a perfect palindrome
- PMID: 6266918
- DOI: 10.1016/0378-1119(81)90032-9
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Extrachromosomal rDNA of Tetrahymena thermophila is not a perfect palindrome
Gene.
1981 Apr.
Abstract
We have determined the restriction-endonuclease-cleavage map and the nucleotide sequence of the central 1.4 kb fragment of the macronuclear extrachromosomal rDNA of Tetrahymena thermophila. These data demonstrate that this molecule is not a perfect palindrome, having a 29 bp AT-rich non-palindromic sequence at its center. This observation is important in determining the mechanism by which a single chromosomally integrated rRNA gene in the micronucleus is rearranged and amplified during sexual development to yield multiple copies of extrachromosomal rDNA in the macronucleus.
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