Lymphocytes infiltrating human breast cancers lack K-cell activity and show low levels of NK-cell activity
- PMID: 6268135
- PMCID: PMC2010737
- DOI: 10.1038/bjc.1981.167
Lymphocytes infiltrating human breast cancers lack K-cell activity and show low levels of NK-cell activity
Abstract
Lymphocytes infiltrating human primary mammary carcinomas lack ADCC and show low levels of natural cytotoxicity. The peripheral blood lymphocytes, however, show a variable but prominent level of cytotoxicity. Lymphocyte preparations from breast tumours, when mixed with autologous blood lymphocytes, significantly suppress their prominent killer- (K- and NK-) cell activities.
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