Relationship of internal cyclic AMP levels, rates of protein synthesis and mucor dimorphism

Abstract

Changes in the intracellular pools of cyclic AMP and specific rates of protein synthesis have been described as correlates of the yeast-to-hypha conversion in Mucor racemosis. A further examination of the relationship between these physiological parameters and the cellular morphogenesis was conducted in the present study. The levels of intracellular cyclic AMP consistently varied as a function of the cell morphology rather than the CO2 tension, oxygen tension or growth rate. The specific rate of protein synthesis failed to change during a N2-to-air-induced yeast-to-hypha transition. Previously reported changes in this parameter during CO2-to-air- and CO2-to-N2-induced yeast-to-hypha shifts may be a consequence of growth rate changes rather than development per se.