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. 1981 Jul;34(7):869-75.
doi: 10.7164/antibiotics.34.869.

Enzymatic adenylylation of spectinomycin by Acinetobacter calcoaceticus subsp. anitratus

S Shimizu, M Inoue, S Mitsuhashi, H Naganawa, S Kondo
Free article

Enzymatic adenylylation of spectinomycin by Acinetobacter calcoaceticus subsp. anitratus

S Shimizu et al. J Antibiot (Tokyo). 1981 Jul.
Free article

Abstract

Spectinomycin (SPC) was inactivated in the presence of adenosine-5'-triphosphate and magnesium ion by an enzyme preparation made from Acinetobacter calcoaceticus subsp. anitratus GN12313 resistant to both SPC and streptomycin. The structure of the inactivated SPC was found to be the adenylylated product of the hydroxy group on C-9 of the actinamine moiety.

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