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Clinical Trial
. 1978 Jan;8(1):65-8.
doi: 10.1111/j.1365-2222.1978.tb00449.x.

The danger of "yellow dyes" (tartrazine) to allergic subjects

I Neuman, R Elian, H Nahum, P Shaked, D Creter
Clinical Trial

The danger of "yellow dyes" (tartrazine) to allergic subjects

I Neuman et al. Clin Allergy. 1978 Jan.

Abstract

Oral administration of 50 mg tartrazine to 122 patients with a variety of allergic disorders caused the following reactions: general weakness, heatwaves, palpitations, blurred vision, rhinorrhoea, feeling of suffocation, pruritus and urticaria. There was activation of the fibrinolytic pathway as shown by reduction of plasminogen with high pre-kallikrein and low kallikrein values. Reduction in complement activity (CH50) was seen in three out of sixteen reactions.

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