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. 1981;16(1):91-103.
doi: 10.1002/jsscb.1981.380160109.

The repair of DNA damage: recent developments and new insights

E C Friedberg, T Bonura, J D Love, S McMillan, E H Radany, R A Schultz

The repair of DNA damage: recent developments and new insights

E C Friedberg et al. J Supramol Struct Cell Biochem. 1981.

Abstract

This brief review presents the salient features of new developments in the enzymatic repair of base damage to DNA. DNA glycosylases and apurinic/apyrimidinic (AP) endonucleases are reviewed and evidence is presented that in at least two prokaryote systems incision of UV-irradiated DNA occurs by the sequential action of these two classes of enzymes. In contradistinction, the uvrA, uvrB, and uvrC gene products of E coli appear to function as a multi-protein complex that catalyzes hydrolysis of phosphodiester bonds in damaged DNA directly. The inducible rapid repair of O6-methylguanine in E coli is also reviewed.

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