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. 1981 Sep;317(2):178-9.
doi: 10.1007/BF00500077.

Loperamide reduces the intestinal secretion but not the mucosal cAMP accumulation induced by choleratoxin

U M Farack, U Kautz, K Loeschke

Loperamide reduces the intestinal secretion but not the mucosal cAMP accumulation induced by choleratoxin

U M Farack et al. Naunyn Schmiedebergs Arch Pharmacol. 1981 Sep.

Abstract

The effect of loperamide on net fluid transport and epithelial cAMP accumulation was tested in choleratoxin-exposed ligated colon loops of the rat in vivo. Purified choleratoxin (50 micrograms/ml saline, for 5 h) induced net secretion and doubled cAMP levels in comparison with saline-treated controls. Loperamide (4 mg/kg intragastrically) reduced this secretion by 75%, without diminishing cAMP accumulation; it had no effect on basal fluid transport or cAMP. The data suggest that the opiate analogue interferes with the secretory process at a point beyond the cAMP increase caused by activation of adenylate cyclase.

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