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. 1981 Sep 11;9(17):4339-54.
doi: 10.1093/nar/9.17.4339.

Transcription of the beta-like globin genes and pseudogenes of the goat in a cell-free system

D S Luse, J R Haynes, D VanLeeuwen, E A Schon, M L Cleary, S G Shapiro, J B Lingrel, R G Roeder

Transcription of the beta-like globin genes and pseudogenes of the goat in a cell-free system

D S Luse et al. Nucleic Acids Res. .

Abstract

We have examined the transcription in a cell-free system of all the members of a highly regulated gene family, the beta-like hemoglobin genes of the goat. These five genes, which code for embryonic, fetal, juvenile, and adult beta-globin proteins, are all transcribed to roughly the same extent in the in vitro system. In all cases initiation of transcription is accurate. However, two goat beta-globin pseudogenes, as well as several artificially constructed deletion mutants, are not transcribed in vitro. A common feature of the transcriptionally inactive genes is the lack of an AT-rich consensus sequence just upstream of the presumptive initiation site.

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