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. 1981 Aug;78(8):4796-800.
doi: 10.1073/pnas.78.8.4796.

Theoretical aspects of translocation on DNA: adenosine triphosphatases and treadmilling binding proteins

T L Hill, T Tsuchiya

Theoretical aspects of translocation on DNA: adenosine triphosphatases and treadmilling binding proteins

T L Hill et al. Proc Natl Acad Sci U S A. 1981 Aug.

Abstract

The basic kinetic and bioenergetic theory is outlined for two kinds of translocation on DNA: (i) helicases that use ATP to move along single-stranded DNA or to move on and invade double-stranded DNA at a replication fork; and (ii) DNA-binding proteins (not ATPases) that form bound aggregates on single-stranded DNA and facilitate replication by steady-state treadmilling of molecules between the ends of the aggregate. The respective resemblances to myosin--actin in muscle and to steady-state treadmilling in solution of actin or tubulin are pointed out.

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