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. 1981 Sep;78(9):5759-63.
doi: 10.1073/pnas.78.9.5759.

Polymorphic DNA region adjacent to the 5' end of the human insulin gene

G I Bell, J H Karam, W J Rutter

Polymorphic DNA region adjacent to the 5' end of the human insulin gene

G I Bell et al. Proc Natl Acad Sci U S A. 1981 Sep.

Abstract

The length of a segment of DNA associated with the human insulin gene, which has been localized to the short arm of chromosome 11, is heterozygous in 63% of 52 individuals analyzed. This polymorphic region is approximately 500 base pairs from the nucleotide encoding the 5' end of insulin mRNA. The polymorphism appears to be due to an insertion or deletion of DNA sequences so that DNA fragments of different length are generated when DNA from a heterozygous individual is digested with selected restriction endonucleases.

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References

    1. J Mol Biol. 1975 Nov 5;98(3):503-17 - PubMed
    1. Annu Rev Genet. 1980;14:145-78 - PubMed
    1. J Mol Biol. 1977 Jun 15;113(1):237-51 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Nov;75(11):5631-5 - PubMed
    1. Cell. 1979 Apr;16(4):739-51 - PubMed

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