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. 1976 Nov 15;18(5):703-9.
doi: 10.1002/ijc.2910180520.

Mast cells and tumor angiogenesis

D A Kessler, R S Langer, N A Pless, J Folkman

Mast cells and tumor angiogenesis

D A Kessler et al. Int J Cancer. .

Abstract

Tumor angiogenesis factor (TAF) elicits a strong vasoproliferative response when implanted upon the chorioallantoic membrane (CAM) of the chick embryo. This response is first observed stereomicroscopically 2-3 days after implantation. A 40-fold increase in mast cell density is observed within the vicinity of this implant by 24 h. Mast cells that have been isolated from retired breeder Sprague-Dawley rats fail to evoke a vascular reaction when implanted on the CAM. An intermediate role for the mast cell in tumor angiogenesis is suggested.

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