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. 1981 Nov;36(2):321-7.
doi: 10.1016/S0006-3495(81)84734-0.

The effect of tetramethylammonium on single sodium channel currents

R Horn, J Patlak, C F Stevens

The effect of tetramethylammonium on single sodium channel currents

R Horn et al. Biophys J. 1981 Nov.

Abstract

Voltage-dependent Na conductance of rat myotubes was studied by patch recordings of single-channels. The patches were excised from the cell with the patch electrode, and the cytoplasmic surface was bathed in either CsF or tetramethylammonium (TMA)-F. Inward currents were examined from -20 to -50 mV. In this range Cs and TMA both appeared to be nearly impermeant, but TMA blocked the channel in a voltage-dependent manner. A first-order blocking site was located a maximum of 89% of the way through the membrane field from the cytoplasmic surface.

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References

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