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. 1981 Dec 10;294(5841):536-40.
doi: 10.1038/294536a0.

Clustered arrangement of immunoglobulin lambda constant region genes in man

P A Hieter, G F Hollis, S J Korsmeyer, T A Waldmann, P Leder

Clustered arrangement of immunoglobulin lambda constant region genes in man

P A Hieter et al. Nature. .

Abstract

The immunoglobulin lambda light chain locus of man contains six lambda-like genes arranged tandemly on a 50-kilobase segment of chromosomal DNA. THe sequences of three of these genes correspond to three known non-allelic lambda chain isotypes: Mcg, Ke-Oz- and Ke-Oz+. They surround a highly polymorphic and evidently unstable region that is repeatedly deleted when cloned in Escherichia coli. Three additional, but as yet unlinked, lambda-like sequences have also been cloned, suggesting that the lambda genes form an unexpectedly large family within the human genome.

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