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. 1981 Oct;78(10):6139-43.
doi: 10.1073/pnas.78.10.6139.

Uninfected cell polymerase efficiently transcribes early but not late herpes simplex virus type 1 mRNA

R J Frink, K G Draper, E K Wagner

Uninfected cell polymerase efficiently transcribes early but not late herpes simplex virus type 1 mRNA

R J Frink et al. Proc Natl Acad Sci U S A. 1981 Oct.

Abstract

The sequences of the DNAs encoding the 5' ends of one early and one late herpes simplex virus type 1 mRNA were analyzed, and the 5' ends of these mRNA species were precisely located. Neither mRNA species is spliced and the noncoding strand of the DNA contains recognizable T-A-T-A and C-A-T boxes upstream from their respective 5' ends. The early mRNA was efficiently transcribed by a commercially available uninfected cell lysate system, but the late mRNA was not. This difference between early and late mRNAs appears to be general in this virus.

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References

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