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. 1981 Nov;78(11):7162-5.
doi: 10.1073/pnas.78.11.7162.

An Epstein--Barr virus early protein induces cell fusion

G J Bayliss, H Wolf

An Epstein--Barr virus early protein induces cell fusion

G J Bayliss et al. Proc Natl Acad Sci U S A. 1981 Nov.

Abstract

Superinfection of Raji cells with Epstein--Barr virus (EBV) leads to syncytium formation. Studies using metabolic inhibitors and amino acid analogues suggest that the fusion-inducing factor belongs to the early group of virus-specified proteins. Induction of early EBV protein synthesis in Raji cells by using various chemicals also leads to syncytium formation, indicating that the fusion process is not caused by a virion membrane protein introduced into the cells upon infection. The relevance of these findings to the association of EBV with carcinoma of the nasopharynx is discussed.

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