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. 1981;18(5):57-63.

[Combined method (suspension-monolayer) of preparing an inactivated foot-and-mouth disease vaccine]

[Article in Bulgarian]
I Genov, G Tivchev, E Veleva, P Tekerlekov, I Shopov
  • PMID: 6275604

[Combined method (suspension-monolayer) of preparing an inactivated foot-and-mouth disease vaccine]

[Article in Bulgarian]
I Genov et al. Vet Med Nauki. 1981.

Abstract

Semiproductional and productional experiments were carried out to cultivate BHK21C13 cells in 30- and 250-litre fermentors, to produce F.M.D. virus in suspension and in roller, and to produce a F.M.D. vaccine in 500-litre automatic mixing containers, employing a combined method 'suspension-monolayer'. The F.M.D. virus that was replicated in suspension had a 10(-6,0-6,5) titer, and the virus that was obtained in monolayer - a 10(-7,0-8,0) titer. It was demonstrated that the F.M.D. vaccines that were produced after the combined method were sterile, innocuous, and immunogenic.

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