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. 1981;175(6):870-3.

[Insensitivity of some rats to intraperitoneal injections of collagenase and trypsin]

[Article in French]
J Warter, H Schirardin, A Warter, D Storck
  • PMID: 6275964

[Insensitivity of some rats to intraperitoneal injections of collagenase and trypsin]

[Article in French]
J Warter et al. C R Seances Soc Biol Fil. 1981.

Abstract

In the rat peritoneal injections of collagenase or trypsin give rise to severe lesions. In our experience 20% of the animals remain intact. The frequency of lesions increases with older and heavier subjects. Moreover 25% of the rats who remained free of lesions after a first injection of collagenase resist to a second one. This shows that they are strongly protected against the enzyme. The exact nature and location of this protective mechanism are not known.

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