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. 1981 Dec 21;9(24):7065-72.
doi: 10.1093/nar/9.24.7065.

Two cloned beta thalassemia genes are associated with amber mutations at codon 39

R Pergolizzi, R A Spritz, S Spence, M Goossens, Y W Kan, A Bank

Two cloned beta thalassemia genes are associated with amber mutations at codon 39

R Pergolizzi et al. Nucleic Acids Res. .

Abstract

Two beta globin genes from patients with the beta(+) thalassemia phenotype have been cloned and sequenced. A single nucleotide change from CAG to TAG (an amber mutation) at codon 39 is the only difference from normal in both genes analyzed. The results are consistent with the assumption that both patients are doubly heterozygous for beta(+) and beta degrees thalassemia, and that we have isolated and analyzed the beta degrees thalassemia gene.

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