Gene amplification in methotrexate-resistant mouse cells. II. Rearrangement and amplification of non-dihydrofolate reductase gene sequences accompany chromosomal changes

C J Bostock et al. J Mol Biol. 1981.

. 1981 Dec 5;153(2):219-36.

doi: 10.1016/0022-2836(81)90275-8.

No abstract available

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Increased dihydrofolate reductase, double minutes and increased nucleolar activation in methotrexate-resistant HeLa cells.
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Amplification units containing human N-myc and c-myc genes.
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Occurrence and evolution of homogeneously staining regions may be due to breakage-fusion-bridge cycles following telomere loss.
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