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. 1982 Feb;79(4):1225-9.
doi: 10.1073/pnas.79.4.1225.

At least two regions of the viral genome determine the oncogenic potential of avian leukosis viruses

H L Robinson, B M Blais, P N Tsichlis, J M Coffin

At least two regions of the viral genome determine the oncogenic potential of avian leukosis viruses

H L Robinson et al. Proc Natl Acad Sci U S A. 1982 Feb.

Abstract

Recombinants of oncogenic and nononcogenic avian leukosis viruses were tested for their oncogenic potential in chickens. The results indicate that at least two regions of the viral genome determine the oncogenic potential of these viruses. The first region contains sequences that control viral mRNA synthesis. These sequences determine the potential of a virus to induce a low incidence of lymphomas, carcinomas, chondrosarcomas, fibrosarcomas, and osteopetrosis. The second region lies outside the sequences that control viral mRNAs synthesis. These sequences determine the ability of a virus to induce a high incidence of lymphomas or osteopetrosis.

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