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. 1976 Nov;117(5 Pt.2):2038-40.

Induction of antibody to the "y" determinant of HBsAg in a chimpanzee carrier of HBsAg subtype "adw"

E Tabor, R J Gerety, L A Smallwood, L F Barker
  • PMID: 62804

Induction of antibody to the "y" determinant of HBsAg in a chimpanzee carrier of HBsAg subtype "adw"

E Tabor et al. J Immunol. 1976 Nov.

Abstract

Antibody to the y determinant of hepatitis B surface antigen (HBsAg) was induced in a chimpanzee chronically infected with hepatitis B virus and circulating HBsAg subtype adw. The chimpanzee was immunized with purified preparations of HBsAg subtypes adw and ayw. Six weeks after immunization, antibody to HBsAg (anti-HBs) specific for the y determinant, appeared. No change occurred in titers of HBsAg or antibody to hepatitis B core antigen (anti-HBc) and "e" antigen remained detectable. The circulating HBsAg subtype adw remained present despite the persistence of anti-y for greater than 8 months.

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