doi: 10.1016/0165-2478(82)90031-1.
Effect of prostaglandins on elicitation of anti-viral-cytolytic activity
- PMID: 6281179
- DOI: 10.1016/0165-2478(82)90031-1
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Effect of prostaglandins on elicitation of anti-viral-cytolytic activity
Immunol Lett.
1982 Mar.
Abstract
We have studied the modulating effect of prostaglandins (PG) on the elicitation of secondary anti-vesicular stomatitis virus (VSV) cytotoxic T-lymphocytes (CTL) with viral antigens. The results indicate that PGE1 and PGE2 both inhibit the induction of anti-VSV CTLs by ultraviolet-inactivated VSV. Consistent with the result was the augmentation of anti-VSV CTL activity when VSV-primed spleen cells were cultured in the presence of indomethacin. These results suggest that PGs may modulate anti-viral CTL responses.
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