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. 1982 Mar;4(3):171-4.
doi: 10.1016/0165-2478(82)90031-1.

Effect of prostaglandins on elicitation of anti-viral-cytolytic activity

A H Hale, D L Evans, L W Daniel

Effect of prostaglandins on elicitation of anti-viral-cytolytic activity

A H Hale et al. Immunol Lett. 1982 Mar.

Abstract

We have studied the modulating effect of prostaglandins (PG) on the elicitation of secondary anti-vesicular stomatitis virus (VSV) cytotoxic T-lymphocytes (CTL) with viral antigens. The results indicate that PGE1 and PGE2 both inhibit the induction of anti-VSV CTLs by ultraviolet-inactivated VSV. Consistent with the result was the augmentation of anti-VSV CTL activity when VSV-primed spleen cells were cultured in the presence of indomethacin. These results suggest that PGs may modulate anti-viral CTL responses.

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